reports

The article prose repeats the IVW P value for the weighted median, while Table 4 and the archived result table report 9.226e-14. The comparator uses the table/archive target and preserves the prose mismatch as a source discrepancy; it is not presented as a skill defect.

TwoSampleMR 0.4.22 produced the same four fixed-seed outputs under the current R 4.3.2 compatibility environment, but the original R 3.5 system and seed were unavailable. Strong IVW heterogeneity remains an interpretation limit. The nonsignificant Egger-intercept test is not proof that directional pleiotropy is absent.